Dr. Dylan Cooke

Postdoctoral Researcher

IMG_1423bCurriculum Vitae

University of California, Davis
Center for Neuroscience
1544 Newton Court
Davis, CA 95618
Tel: (530) 754-7569
Fax: (530) 757-8827

dfcooke at ucdavis dot edu

Ph. D., Princeton University , Psychology and Neuroscience, 2005 in the laboratory of Michael Graziano
A.B., Princeton University , Psychology magna cum laude, 1999

MAIN RESEARCH INTERESTS:

One of the challenges of studying functional organization of the brain
is that perturbations to neural circuitry are followed by rapid
changes in functional organization and behavior. For example, focal
parietal lesions in monkeys produce transient manual deficits which
disappear within 2-4 days, making systematic study of the effects of
focal lesions extremely difficult.

We have developed a novel cooling implantable cooling device designed
to reversibly inactivate small portions of cortex for the purpose of
studying brain function and organization. We are using this device to
study the role of monkey parietal areas in the control of specific
manual behaviors, but we believe that this cooling device will be
useful in a variety of species for a wide range of studies of the
brain. We have adapted materials not used in other neural cooling
devices, creating a non-metallic design of silicone tubing embedded in
PDMS silicone. The result is extremely lightweight and flexible.

Fig-7-(1)

Regulation of cortical temperature. Automated feedback control of
brain temperature (bottom trace) was achieved by regulation of coolant
flow rate (top trace) in an anesthetized monkey. A PID control
algorithm used cortical temperature as feedback to regulate thermal
dynamics. Temperature was monitored with a microthermocouple in cortex
600 µm below a cooling chip located on the pial surface of area 2.
Gray boxes indicate experimenter-specified target temperatures (± 0.3
°C). Target temperature was achieved in <60 s. Overshoot was <0.5 °C
and post-overshoot was well within ± 0.3 °C. Resting temperature (~35
°C) was several degrees lower than normal because brain was exposed to
the air. Automated feedback control performance was similar in awake
monkeys.

Fig-13